An Intervention to Improve Medication Adherence in People With Heart Disease (Text4HeartII): Randomized Controlled Trial

Background Mobile health technologies have the potential to improve reach and delivery of interventions for promoting long-term secondary prevention coronary heart disease. Objective This study aims determine effectiveness an SMS text messaging intervention (Text4HeartII) improving adherence medication lifestyle changes over above usual care in people with disease at 24 52 weeks. Methods A two-arm, parallel, randomized controlled trial was conducted New Zealand. Participants a recent acute syndrome were receive cardiac services alone (control, n=153) or 24-week message program supporting self-management plus (n=153). The primary outcome weeks, defined as possession ratio 80% more aspirin, statin, antihypertensive therapy. Secondary outcomes included self-reported adherence, healthy behaviors, health-related quality life Results predominantly male (113/306, 80.3%) European Zealanders (210/306, 68.6%), mean age 61 years (SD 11 years). Groups comparable baseline. National hospitalization pharmacy dispensing records available all participants; 92% (282/306, 92.1%) participants completed questionnaire 95.1% (291/306) 52-week questionnaire. Adherence 3 classes lower group than control (87/153, 56.8% vs 105/153, 68.6%, odds 0.60, 95% CI 0.38-0.96; P=.03) weeks (104/153, 67.9% 83/153, 54.2%; 0.56, 0.35-0.89; P=.01). Self-reported scores showed same trend (mean difference 0.3; 0.01-0.59; P=.04). Moreover, behaviors similar between groups. Conclusions Text4HeartII did not dispensed favorable care. finding contrasts previous studies highlights that benefits may depend on context which they are used. Trial Registration Australian Zealand Clinical Trials Registry ACTRN12616000422426; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370398. International Registered Report Identifier (IRRID) RR2-10.1186/s13063-018-2468-z